Hyperbaric oxygen intervention on expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in spinal cord injury models in rats |
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作者姓名: | ZHOU Yi LIU Xue-hu QU Shao-dong YANG Jing WANG Zhi-wei GAO Chun-jin SU Qing-jun |
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摘 要: | Background Hyperbaric oxygen (HBO) intervention is a main therapeutic method and the curative effect has been certified for spinal cord injury (SCI), but the mechanisms of the neuroprotective effect of HBO on SCI remain elusive. This study aimed to observe the change in expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) after SCI at different time points and to investigate the neuroprotective mechanism of HBO on SCI in rats.
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关 键 词: | 缺氧诱导因子-1 血管内皮生长因子 脊髓损伤 高压氧 损伤模型 大鼠 保护机制 HIF-1 |
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