| 脂联素水平与2型糖尿病视网膜病变关系研究 |
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| 引用本文： | liyuan han,Xiao-hong FAN,Qun-hong WU,Yuan LI,Yan-hua HAO,Ning NING,Zheng KANG,Yu CUI,Ruo-hong LIU. 脂联素水平与2型糖尿病视网膜病变关系研究[J]. 中华医学杂志(英文版), 2014, 127(4) |
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| 作者姓名： | liyuan han Xiao-hong FAN Qun-hong WU Yuan LI Yan-hua HAO Ning NING Zheng KANG Yu CUI Ruo-hong LIU |
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| 作者单位： | Department of Preventive Medicine, Medical School of Ningbo University, Ningbo315021,Zhejiang province, People’s Republic of China,Department of Social Medicine, School of Public Health, Harbin Medical University,157 Baojian Road, Harbin 150081, Heilongjiang province, People’s Republic of China,Department of Social Medicine, School of Public Health, Harbin Medical University,157 Baojian Road, Harbin 150081, Heilongjiang province, People’s Republic of China,Department of Social Medicine, School of Public Health, Harbin Medical University,157 Baojian Road, Harbin 150081, Heilongjiang province, People’s Republic of China,Department of Social Medicine, School of Public Health, Harbin Medical University,157 Baojian Road, Harbin 150081, Heilongjiang province, People’s Republic of China,Department of Social Medicine, School of Public Health, Harbin Medical University,157 Baojian Road, Harbin 150081, Heilongjiang province, People’s Republic of China,Department of Social Medicine, School of Public Health, Harbin Medical University,157 Baojian Road, Harbin 150081, Heilongjiang province, People’s Republic of China,Department of Social Medicine, School of Public Health, Harbin Medical University,157 Baojian Road, Harbin 150081, Heilongjiang province, People’s Republic of China,Wenhua community clinics, Qiqihar 161005, Heilongjiang province, People’s Republic of China |
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| 摘 要： | 研究背景：脂联素水平与糖尿病视网膜病变之间的关系尚无一致性结论。我们通过meta分析来探讨脂联素水平与糖尿病视网膜病变之间的关系。方法：我们通过检索Pubmed、Cochrane Library、Medline、Embase、万方、中国知网等数据库中脂联素水平与糖尿病视网膜关系的研究，按照已拟定的标准进行筛选，对符合标准的研究采用meta分析的方法进行系统性评价，借助统计分析软件Stata 11.0评价研究间异质性，并根据检验结果选用随机效应模型或固定效应模型进行数据合并，计算合并SMD值及95%Cl，同时通过分层亚组分析及meta回归探讨异质性的来源，用漏斗图、Begg与Egger检验检测发表偏倚。结果：我们一共纳入了13个研究，包括1214例病例与1249例对照，原始的meta分析未发现脂联素水平在糖尿病视网膜病变组与无糖尿病视网膜病变组之间存在差别。然而删除了具有异质性的文章之后，第二次meta分析也未发现脂联素水平与糖尿病视网膜病变存在关联，未发现异质性与发表偏倚。根据现存的数据，在中国人群中未发现脂联素水平在无糖尿病视网膜病变与非增殖性糖尿病视网膜病变，非增殖性糖尿病视网膜病变与增殖性糖尿病视网膜病变之间存在显著性差异。结论：我们的meta分析未发现脂联素水平在糖尿病视网膜发展的不同阶段是降低还是升高。脂联素水平与糖尿病视网膜病变之间的关系还需要更大样本量及更深入的研究。
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| 关 键 词： | 关键词：脂联素水平；meta分析；糖尿病视网膜病变 |
Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes |
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| Abstract: | |
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| Keywords: | Adiponectin concentrations Meta-analysis Diabetic Retinopathy |
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