Modified exercise test in screening for mitochondrial myopathies--adjustment of workload in relation to muscle strength |
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Authors: | Hammarén Elisabet Rafsten Lena Kreuter Margareta Lindberg Christopher |
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Institution: | Neuromuscular Centre, Department of Neurology, Sahlgrenska University Hospital, M?lndal, Sweden. elisabet.hammaren@vgregion.se |
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Abstract: | The aim of this study was to evaluate the usefulness of a modification of the bicycle ergometer test, the subanaerobic threshold exercise test (SATET), as a screening test for patients with mitochondrial myopathies. Since the original SATET is frequently found to be strenuous for weak patients, a new variable (relative muscle strength) was added to the workload formula. Plasma lactate levels were recorded at rest, then after 5 and 15 min of cycling on an ergometer, with constant workload. Nine patients with mitochondrial myopathy, 10 patients with other neuromuscular diseases and 9 healthy but sedentary volunteers undertook the test. An upper reference limit after exercise for plasma lactate was settled at 2.9 mmol/l. The modified SATET showed a sensitivity of 78% and a specificity compared to the healthy subjects of 100%. Compared to patients with other neuromuscular diseases, the specificity was lower (60%). All subjects completed the test without severe fatigue or pain. |
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