Effect from prophylactic administration of pentoxyphylline (trental) on the development of neuropathic pain syndrome and on the associated microcirculatory disturbances

Prophylactic injection of pentoxyphylline into rats with a neuropathic pain syndrome produced by sciatic nerve transection delayed and weakened the development of this syndrome, improved the microcirculation and venular permeability, and reduced mast cell degranulation. The findings of this study recommend pentoxyphylline for clinical use in the multidrug treatment of neuropathic pain syndromes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 5, pp. 485–487, May, 1995 Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences