| Effects of PAF and PAF antagonist WEB 2170 on relaxation of vascular endothelium after brief deoxygenation and reoxygenation |
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| 引用本文： | 韩雅玲,陈思聪,郑钦岳,张国元,李少华,吴宗贵. Effects of PAF and PAF antagonist WEB 2170 on relaxation of vascular endothelium after brief deoxygenation and reoxygenation[J]. 中国人民解放军军医大学学报, 1995, 0(1) |
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| 作者姓名： | 韩雅玲 陈思聪 郑钦岳 张国元 李少华 吴宗贵 |
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| 作者单位： | Han Yaling; Chen Sicong; Zheng Qinyue; Zhang Guoyuan; LiShaohua; Wu Zonggui(Department of Cardiology，Changzheng Hospital，Second Military Medical University，Shanghai，200433 |
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| 摘 要： | ＥｆｆｅｃｔｓｏｆＰＡＦａｎｄＰＡＦａｎｔａｇｏｎｉｓｔＷＥＢ２１７０ｏｎｒｅｌａｘａｔｉｏｎｏｆｖａｓｃｕｌａｒｅｎｄｏｔｈｅｌｉｕｍａｆｔｅｒｂｒｉｅｆｄｅｏｘｙｇｅｎａｔｉｏｎａｎｄｒｅｏｘｙｇｅｎａｔｉｏｎＨａｎＹａｌｉｎｇ（韩雅玲）；Ｃｈｅ...
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Effects of PAF and PAF antagonist WEB 2170 on relaxation of vascular endothelium after brief deoxygenation and reoxygenation |
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| Han Yaling, Chen Sicong, Zheng Qinyue, Zhang Guoyuan, LiShaohua, Wu Zonggui. Effects of PAF and PAF antagonist WEB 2170 on relaxation of vascular endothelium after brief deoxygenation and reoxygenation[J]. Journal of Medical Colleges of PLA(China), 1995, 0(1) |
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| Authors: | Han Yaling Chen Sicong Zheng Qinyue Zhang Guoyuan LiShaohua Wu Zonggui |
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| Abstract: | By means of the tension determination of rat thoracic aortic ring. it was found that PAF depressed the acetylcholine (Ach)-induced relaxation of the rings, having undergone 20 min of deoxygenation followed by 30 min of reoxygenation, to 36. 1% of norepinephine(NE) precontraction. PAF receptor antagonist WEB 2170 markedly improved the Ach-induced relaxation of the brief deoxygenated and reoxygenated rings to 86. 7 % of NE precontraction. The results indicated that PAF may be one of the mediators involved in the endothelium relaxation dysfunction related to brief deoxygenation and reoxygenation, and that PAF antagonist WEB 2170 has the protective effect on endothelium relaxation function. |
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| Keywords: | platelet activating factor anoxemia acetylcholine endothelium vascular rats |
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