新型网织红细胞参数在缺铁性贫血疗效观察中的应用

目的　观察网织红细胞绝对数 (RET #)、网织红细胞内血红蛋白量 (CHr)、平均网织红细胞体积 (MCVr)及网织红细胞内血红蛋白浓度 (CHCMr)等网红参数在缺铁性贫血 (IDA)患者铁剂治疗中的动态变化 ,确定骨髓对铁剂治疗反应的早期指标。方法　用Advia 12 0血细胞分析仪对 13例缺铁性贫血患者在治疗过程中网红参数的变化进行了动态观察。结果　缺铁性贫血患者在铁剂治疗后 ,网红参数RET #、CHr、MCVr于第 4天明显升高 (P <0 0 1) ,第七天恢复正常 ;血红蛋白于第 14天明显升高 (P <0 0 1) ,第 2 8天恢复正常 ;CH、MCV、CHCM于第 2 8天明显升高 (P <0 0 1) ,第 4 9天后恢复正常 ;RDW于第 7天明显升高 (P <0 0 1) ,14天后又逐渐降低 ,第 12 0天恢复正常。结论　网红参数RET #、CHr、MCVr可作为评价缺铁性贫血患者铁剂治疗后骨髓对治疗反应最敏感的指标

The application of new reticulocyte indices on iron therapy of IDA

Objective To obtain an early indicator of marrow reaction in iron therapy of IDA by observing the change of absolute reticulocyte count(RET#),mean reticulocyte corpuscular volume(MCVr)?reticulocyte hemoglobin content(CHr)?reticulocyte hemoglobin concentration mean(CHCMr) from patients with iron deficiency anemia(IDA). Method Reticulocyte and other red blood cell indices in 13 patients with iron deficiency anemia(IDA) were determined on Advia 120 hematology analyzer during follow up of iron therapy .Results After iron therapy,RET#,CHr,MCVr significantly increased( P <0 01)at the 4 th day,back to normal at the 7 th day.Hemoglobin(Hb) significantly increased ( P <0 01) at the 14 th day,back to normal at the 28 th day.Mean corpuscular volume(MCV),hemoglobin content of red blood cell(CH) and cell hemoglobin concentration mean (CHCM) significantly increased( P <0 01) at the 28 th day,back to normal at the 49 th day.Red cell volume distribution width(RDW) significantly increased( P <0 01) at the 7 th day and then,gradually decreased after 14 days,back to normal at the 120 th day.Conclusion RET#,CHr and MCVr are the most sensitve indicators to evaluate the effect of iorn therapy on bone marrow from IDA patients.