| 过氧化物酶体增殖激活物受体γ在皮肤自然衰老过程中的表达及意义 |
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| 引用本文： | 钟连生,刘彦群,魏志平,李凤朝. 过氧化物酶体增殖激活物受体γ在皮肤自然衰老过程中的表达及意义[J]. 中国中西医结合皮肤性病学杂志, 2008, 7(1): 10-12 |
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| 作者姓名： | 钟连生 刘彦群 魏志平 李凤朝 |
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| 作者单位： | 徐州医学院附属医院,徐州,221002 |
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| 摘 要： | 目的研究过氧化物酶体增殖激活物受体γ（PPARγ）在皮肤自然衰老过程中的表达及其意义。方法采用免疫组化方法（SP法）检测PPARγ的蛋白表达水平，RT—PCR方法检测PPARγ的mRNA表达水平。结果免疫组化研究结果表明中老年组PPARγ蛋白的表达强度显著高于青少年组（x^2=15．48，P=0．001）；RT—PCR检测结果表明中老年组PPARγmRNA的平均表达水平为0．697±0．204，青少年组为0．337±0．124，中老年组亦显著高于青少年组（t=8．25，P〈0．001）。结论随着年龄的增加，皮肤PPARγ的表达增高，在皮肤自然老化过程中可能起重要作用，PPARγ有可能成为研制延缓皮肤自然衰老药物的新靶点。
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| 关 键 词： | 皮肤 自然衰老 过氧化物酶体增殖激活物受体γ |
| 文章编号： | 1672-0709(2008)01-0010-03 |
| 修稿时间： | 2007-12-24 |
Expression of Peroxisome Proliferator-Actived Receptorγ in the Process of Skin Intrinsic Aging |
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| ZHONG Lian-sheng,LIU Yan-qun,WEI Zhi-ping,LI Feng-chao. Expression of Peroxisome Proliferator-Actived Receptorγ in the Process of Skin Intrinsic Aging[J]. Chinese J of Dermatovenerology Integr Tradit and West Med, 2008, 7(1): 10-12 |
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| Authors: | ZHONG Lian-sheng LIU Yan-qun WEI Zhi-ping LI Feng-chao |
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| Affiliation: | ZHONG Lian-sheng, LIU Yan-qun, WEI Zhi-ping, LI Feng--chao Department of Dermatolosy, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China |
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| Abstract: | Objective To investigate the expression of peroxisome proliferators-actived receptorγ（PPARγ） in unexposed skin at different ages and to evaluate its possible significance. Methods The expression of PPARγprotein was detected by immunohistochemistry methods. The mRNA expression of PPARγwas detected by RT-PCR methods Results The expression of both the PPARγprotein and PPARγmRNA were markedly increased with the increasing of age. Conclusion The expression of PPARγis significantly increased with the increasing of age. PPARγmay play a role in the process of skin intrinsic aging and PPARγmay be a novel target in preventing the process of skin intrinsic aging. |
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| Keywords: | skin intrinsic aging peroxisome proliferators-actived receptorγ |
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