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Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas |
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| Authors: | Francesca R. Buttarelli Maura Massimino Manila Antonelli Libero Lauriola Paolo Nozza Vittoria Donofrio Antonella Arcella Maria A. Oliva Concezio Di Rocco Felice Giangaspero |
| Affiliation: | 1. Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy 2. Pediatric Unit, IRCCS Istituto Nazionale Tumori, Milan, Italy 3. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy 4. Department of Anatomic Pathology, Università Cattolica del Sacro Cuore, Rome, Italy 5. Department of Anatomic Pathology, Istituto G. Gaslini Ospedale Pediatrico IRCCS, Genoa, Italy 8. Department of Pathology, Ospedale Pausilipon AORN Santobono-Pausilipon, Naples, Italy 7. IRCCS Neuromed, Pozzilli, Isernia, Italy 6. Neurosurgery Institute, Università Cattolica del Sacro Cuore, Rome, Italy 10. Neuropatologia c/o Neurochirurgia, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy 9. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy |
| Abstract: | IntroductionIn this study, we investigated the prognostic and predictive value of MGMT promoter methylation and protein expression in 30 pediatric high grade gliomas (pHGG). |
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