10日序贯疗法根除幽门螺杆菌的疗效研究

目的:比较10日序贯疗法与传统三联疗法根治幽门螺杆菌(Hp)的疗效与安全性。方法:选取82例1月内14C尿素呼气试验阳性病例,随机分为两组:治疗组前5 d予雷贝拉唑、阿莫西林,后5 d予雷贝拉唑、替硝唑、克拉霉素治疗;对照组予雷贝拉唑加阿奠西林、克拉霉素治疗7 d。疗程结束1个月后行14C尿素呼气试验检测。结果:治疗组根除率95.00%,对照组根除率78.57%,两组比较差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:10日序贯疗法治疗Hp的根治率较传统三联疗法高,且不良反应少,安全可靠。

Eradication of Helicobacter pylori with 10-day sequential therapy

Objective To compare 10 days sequential（including rabeprazole、amoxilli、clafithromyein and tinidazole） and 7 days traditional（including rabeprazole amoxillin and clarithromycin）therapy for eradieation of helicobacter pylori.Methods 82 patients with Hp positive peptic ulcer and chronic gastritis were randomly divided into two groups.40 patients were treated with rabeprazole,amoxillin at first five days;rabeprazole,clarithromycin and tinidazole at the second five daysThe control group（42 patients）were treated with rabeprazole,amoxillin and clarithromycin for seven days.Results The eradication rate of ten days sequential therapy was 95.00%and that of control group was 78.57%.The differences between two groups were significant（P〈0.05）.Conclusion Ten days sequential therapy is more effective,well-tolerated and with higher rate of eradication.