| THE EFFECT OF BASIC FIBROBLAST GROWTH FACTOR SLOW-RELEASE MICROCAPSULES ON ANGIOGENESIS IN INFARCTED RABBIT MYOCARDIUM |
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| 作者姓名： | 朱洪生 连锋 郑家豪 |
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| 作者单位： | Zhu Hongsheng，Lian Feng and Zheng Jiahao Department of Cardiothoracic Surgery，Renji Hospital，Shanghai Second Medical University，Shanghai 200001 |
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| 基金项目： | ThisworkwassupportedbyShanghaiScienceDevelopingFoundation(No .994 1190 4 3) |
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| 摘 要： | ＩＮＴＲＯＤＵＣＴＩＯＮ Ｂａｓｉｃｆｉｂｒｏｂｌａｓｔｇｒｏｗｔｈｆａｃｔｏｒ (ｂＦＧＦ)ｉｓａｎｉｎｔｅｎｓｅｌｙｍｉｔｏｇｅｎｉｃａｓｗｅｌｌａｓａｎｇｉｏｇｅｎｉｃｓｉｎｇｌｅｃｈａｉｎ 1 7 2ｋＤｐｅｐ ｔｉｄｅ ,ｗｈｉｃｈｉｓｗｉｄｅｌｙｄｉｓｔｒｉｂｕｔｅｄｉｎｂｌｏｏｄｖｅｓｓｅｌｓ ,ｃａｒｄｉａｃｔｉｓｓｕｅｓａｎｄｏｔｈｅｒｏｒｇａｎｓ .ＩｎｖｉｖｏａｄｍｉｎｉｓｔｒａｔｉｏｎｏｆｂＦＧＦｌｅａｄｓｔｏｍｙｏｃａｒｄｉｕｍａｎｇｉｏｇｅｎｅｓｉｓｔｈａｔｈａｓｂｅｅｎｄｅｍｏｎ…
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| 关 键 词： | 基础纤维原细胞生长因子 缓慢释放微囊体 bFGF 心肌梗死 动物模型 实验 |
THE EFFECT OF BASIC FIBROBLAST GROWTH FACTOR SLOW-RELEASE MICROCAPSULES ON ANGIOGENESIS IN INFARCTED RABBIT MYOCARDIUM |
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| Zhu Hongsheng,Lian Feng and Zheng Jiahao.THE EFFECT OF BASIC FIBROBLAST GROWTH FACTOR SLOW-RELEASE MICROCAPSULES ON ANGIOGENESIS IN INFARCTED RABBIT MYOCARDIUM[J].Chinese Medical Sciences Journal,2000,15(4):210-213. |
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| Authors: | Zhu Hongsheng Lian Feng and Zheng Jiahao |
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| Institution: | Department of Cardiothoracic Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001. |
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| Abstract: | OBJECTIVES: To observe the effect of basic fibroblast growth factor (bFGF) slow-release microcapsules on angiogenesis in infarcted myocardial regions. METHODS: Myocardial infarction was induced in 24 New Zealand rabbits by ligating the root of left anterior descending coronary artery. Group I (n = 8) served as control, group II (n = 8) as a blank microcapsule group, group III (n = 8, each microcapsule contains 1 microg bFGF) as microcapsule group. In group II and III, 5 blank microcapsules or bFGF slow-release microcapsules were implanted into myocardium underneath the epicardium between the left anterior descending coronary artery and left circumflex artery. Infarct size was evaluated by infarcted weight/left ventricle weight ratio and angiogenesis was evaluated by immunohistochemical examinations 5 weeks later. RESULTS: As compared with group I and II, rabbits treated with bFGF slow-release microcapsules showed higher microvessel counts (group I 37.75 +/- 4.50, group II 38.37 +/- 4.98, vs x group III 135.50 +/- 4.81, P < 0.001) and less infarcted weight/left ventricle weight (group I 16.8% +/- 0.4%, group II 16.7% +/- 0.5%, vs x group III 7.0% +/- 0.2%, P < 0.001). CONCLUSIONS: Subepicardial administration of bFGF slow-release microcapsule in the infarcted rabbit model results in effective angiogenesis and reduction in infarct size. |
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| Keywords: | basic fibroblast growth factor (bFGF) angiogenesis slow-release microcapsule |
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