2型糖尿病患者黄斑区硬性渗出与血脂异常的关系

目的探讨有重度非增生性糖尿病视网膜病变的2型糖尿病患者黄斑区硬性渗出的程度与各项血脂指标异常之间的关系。方法对90例（90眼）诊断为重度非增生性糖尿病视网膜病变的2型糖尿病患者，用中央50。数字彩色眼底照片分析硬性渗出的范围并依据视网膜硬性渗出的程度进行分组：黄斑区未见明显硬性渗出者为A组；黄斑区有硬性渗出且硬性渗出面积〈1／2视盘面积者为B组；黄斑区有硬性渗出且硬性渗出面积≥1／2视盘面积者为C组，各30例。记录各组患者的年龄、性别、病程、胰岛素治疗情况及血压、血Cr水平并进行血脂分析（TC、LDL—C、HDL—C、TG）。结果A、B、C组患者血清Cr分别为（88±31）、（103±24）、（106±42）mmol／L，TC分别为（4．9±2．6）、（5．34-1．2）、（5．9±1．3）mmol／L．LDL—C分别为（2．9±0．9）、（3．1±1．1）、（3．5±1．0）mmol／L，TG分别为（1．7±0．5）、（2．0±0．7）、（2．1±0．7）mmol／L，组间比较差异均有统计学意义（P〈0．05或P〈0．01）。A、B、C组患者血HDL．C差异无统计学意义分别为（1．16±0．19）、（1．14±0．22）、（1．17±0．24）mmol／L，P〉0．05]。结论2型糖尿病患者黄斑水肿的硬性渗出程度与患者血清TC、LDL、TG水平相关。

Association between hard exudates in macular area and dyslipidemia in type 2 diabetic patients with severe non-proliferative diabetic retinopathy

Objective To explore the association between retinal hard exudates and the dyslipidemia in type 2 diabetic patients with severe non-proliferative diabetic retinopathy. Methods All 90 type 2 diabetic patients （90 eyes） of severe non-proliferative diabetic retinopathy were selected. In these patients the retinal hard exudates were graded on a central fundus picture. The patients were divided into three groups： absent or minimal hard exudates （group A） , hard exudates less than 1/2 disk area （group B） and prominent hard exudates more than 1/2 disk area （ group C） ; each group contained 30 patients. Risk factors including the age of onset of diabetes and its duration, gender, insulin therapy, and various systemic parameters like hypertension, glycosylated hemoglobin, serum creatinine levels, complete lipid profile including total cholesterol, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, and triglyceride （TG） were studied. Results In A, B and C group, the levels of serum creatinine were （88 ± 31 ） , （103± 24） , （106 ± 42）mmol/L respectively; TC was （4.9±2.6）, （5.3±1.2）, （5.9±1.3）mmol/L; LDL-Cwas （2.9±0.9）, （3.1±1.1）, （3.5±1.0）mmol/L; TG was （ 1.7 ± 0.5 ）, （2.0 ± 0.7 ）, （2.1± 0.7 ） mmol/L. Among three groups, the levels of serum creatinine, TC, LDL-C and TG were significantly different （ P 〈 0.05 or P 〈 0.01 ） , while the levels of HDL-C had not significant difference （ 1.16 ± 0. 19 ）, （ 1.14 ± 0. 22） and （ 1.17 ± 0. 24 ） retool/L, respectively, P 〉 0. 05 ]. Conclusions The extent of hard exudates in macular area of type 2 diabetic patients with severe non-proliferative diabetic retinopathy is related with levels of TC, LDL-C and TG.