| 人工骨质材料的生物学特性 |
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| 引用本文： | 陈丙年,李智,王宏芳,李娟.人工骨质材料的生物学特性[J].吉林大学学报(医学版),2006,32(4):571-574. |
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| 作者姓名： | 陈丙年 李智 王宏芳 李娟 |
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| 作者单位： | 厦门大学医院外科,福建,厦门,361005;吉林大学公共卫生学院卫生化学教研室,吉林,长春,130021 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 目的：制备表征多金属氧酸盐(POMs)纳米粒子掺杂的羟基磷灰石骨替代材料，并对其性能进行探讨。
方法：用小鼠和白化兔，通过急性毒性实验、热原实验、皮内实验进行生物相容性检验。
结果：材料为棒状，平均粒径为20 nm, 长度为100 nm左右。尺寸与人骨更接近，且POMs纳米粒子掺杂的壳聚糖/羟基磷灰石(CS/nano-HAP)复合材料无热原性，无毒，受试材料浸提液无刺激性。
结论：此多金属氧酸盐纳米粒子掺杂的羟基磷灰石骨替代材料具有良好的生物相容性。这种材料与骨组织结合是一种骨性结合，具有较高的界面强度。
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| 关 键 词： | 羟基磷灰石类 骨代用品 多金属氧酸盐 生物相容性材料 |
| 文章编号： | 1671-587X(2006)04-0571-04 |
| 收稿时间： | 2005-12-21 |
| 修稿时间： | 2005年12月21日 |
Biological characteristics of artificial bones |
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| CHENG Bing-nian,LI Zhi,WANG Hong-fang,LI Juan.Biological characteristics of artificial bones[J].Journal of Jilin University: Med Ed,2006,32(4):571-574. |
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| Authors: | CHENG Bing-nian LI Zhi WANG Hong-fang LI Juan |
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| Institution: | 1. Deparment of Surgery,Hospital of Xiamen University, Xiamen 361005, China;2. Department of Hygienic Chemistry, Schoolof Public Health, Jilin University, Changchun 130021, China |
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| Abstract: | Objective To synthesize a novel polymer POMs-CS/nano-HAP and study its biocompatibility and safety.Methods The biocompatibility was evaluated through the experiments including acute systemic toxicity test,pyrogen,intracutaneous test.Results The crystals of POMs-CS/nano-HAP were equal on sizes, which average diameter was 20 nm and length was 100 nm.By comparing,the polymer were better than those reported,which were closer to the natural bone.The material had no toxicity,no irritation to skin.(Conclusion The) POMs-CS/nano-HAP artificial bone possesses excellent biocompatibility. |
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| Keywords: | hydroxy apatites bone substitutes polyoxometalates biocompatible materials |
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