苦参凝胶联合氟康唑胶囊治疗霉菌性阴道炎的临床观察

霉菌性阴道炎为妇科常见病、多发病,临床易反复发作,给患者带来极大痛苦。本研究通过观察苦参凝胶联合氟康唑胶囊治疗霉菌性阴道炎的临床疗效,旨在寻求一种治疗霉菌性阴道炎的有效方法。笔者将2012年12月—2014年7月本院就诊的85例霉菌性阴道炎患者随机分为治疗组43例和对照组42例,治疗组给予苦参凝胶阴道上药,每晚1次,每次1支,7 d为1个疗程,连用14 d,同时口服氟康唑胶囊治疗,每次150 mg,每3天1次,共4次;对照组单纯给予口服氟康唑胶囊治疗。观察2组患者的总体疗效、治愈率、复发率及临床症状改善情况。结果显示治疗组和对照组的总有效率、治愈率和复发率分别为97.7%,90.7%,2.6%;83.3%,71.4%,20.0%。2组相比差异具有统计学意义(P<0.05);治疗组的白带减少、外阴瘙痒消失、外阴阴道疼痛消失及黏膜充血消失的时间明显少于对照组,差异亦具有统计学意义(P<0.05)。结果表明,苦参凝胶联合氟康唑胶囊治疗霉菌性阴道炎使全身用药与局部用药相结合,可提高药物抗真菌活性,明显改善患者临床症状,缩短病程,提高治愈率、降低复发率,值得在临床推广应用。

Clinical observation on treatment of mycotic vaginitis with Sophora gel combined with Fluconazole capsules

Mycotic vaginitis is a common and frequently-occurring gynaecopathia and easy to attack repeatedly, so painful to patients. In this study, the authors observed the clinical efficacy of Sophora gel combined with Fluconazole capsules in treating mycotic vaginitis, in order to seek an effective method for treating mycotic vaginitis. Totally 85 patients with mycotic vaginitis treated in our hospital between December 2012 and July 2014 were randomly divided into the treatment group (43 patients) and the control group (42 patients). The treatment group was given vaginally Sophora gel (one piece every night for 14 days) and orally Fluconazole capsules (150 mg, once every three days, four times in total); The control group was only administered with Fluconazole capsules. The total efficacy, cure rate, recurrence rate and clinical symptom improvements of the two groups were observed. The results show that the total efficacy, the cure rate and the recurrence rate of the treatment group vs. the control group were respectively 97.7%, 90.7% and 2.6% vs. 83.3%, 71.4% and 20.0%, with statistical significance in their differences (P<0.05). The treatment group showed reduced leucorrhea, pruritus vulvae disappearance and earlier mucosal hyperemia disappearance than the control group, with statistical significance in their differences (P<0.05). In conclusion, Sophora gel combined with Fluconazole capsules can improve antifungal activity of drugs, relieve clinical symptoms, shorten the course of disease, enhance the cure rate and reduce the recurrence rate; So this therapy can be widely applied in clinic.