Undifferentiated Spindle-Cell Sarcoma of the Chest Wall with Vascular Endothelial Growth Factor Expression: Report of a Case |
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Authors: | Akira Iyoda Kenzo Hiroshima Toshikazu Yusa Yoshiaki Tsukamoto Tetsuya Toyozaki Takehiko Fujisawa Hidemi Ohwada |
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Institution: | (1) Division of Pathology and,;(2) Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan, JP;(3) Department of Respiratory Surgery, Chiba Rosai Hospital, Chiba, Japan, JP |
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Abstract: | The expressions of some growth factors have been immunohistochemically confirmed in several kinds of tumors, and in particular
the expression of vascular endothelial growth factor (VEGF) has been reported to be closely related to tumor cell proliferation.
We report herein a case of undifferentiated spindle-cell sarcoma arising in the chest wall with VEGF expression. A 67-year-old
man, who presented with coughing, was found to have an abnormal shadow on his right chest wall. He was admitted to Chiba Rosai
Hospital and preoperative diagnosis of the tumor was sarcoma. The tumor was thus resected along with the right chest wall
and right lower lobe of the lung. Histopathologically, the tumor cells were spindle-shaped and showed severe atypism. The
tumor cells were positive for vimentin and VEGF antibody with immunohistochemical staining, but they did not show differentiation
to any special type of sarcoma. The tumor was diagnosed to be undifferentiated spindle-cell sarcoma. The microvessel density
of the tumor was measured using CD34 and it was found to be higher than the average density of usual sarcomas. The prognosis
of this case was poor. The patient died of tumor metastasis to the lung and bone 1 year later in spite of the fact that the
tumor was resected.
Received: September 1, 1999 / Accepted: March 24, 2000 |
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Keywords: | Spindle cell sarcoma Chest wall Vascular endothelial growth factor |
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