A-raf oncogene localizes on mouse X chromosome to region some 10–17 centimorgans proximal to hypoxanthine phosphoribosyltransferase gene |
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| Authors: | Philip Avner Maja Bućan Danielle Arnaud Hans Lehrach Ulf Rapp |
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| Institution: | (1) Unite d'Immunogenetique Humaine, INSERM U276, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15;(2) European Molecular Biology Laboratory, Postfach 10.2209, 69 Heidelberg, F.R.G.;(3) The Laboratory of Viral Carcinogenesis, Division of Cancer Etiology, National Cancer Institute NIH, Frederick Cancer Research Laboratory, 21701 Frederick, Maryland |
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| Abstract: | The localization of the A-rafcellular oncogene on the mouse X chromosome has been determined using Xbal-restricted DNAs prepared from progeny of an interspecies backcross between the B6.CBA.R1 and the Spe/Pas mouse strains. This localization to the proximal part of the mouse X chromosome has been confirmed by the use of somatic cell hybrids, carrying partially deleted X chromosomes and suggests that the A-raf oncogene localizes to a region lying some 10–17 centimorgans proximal to the hypoxanthine phosphoribosyltransferase (Hprt) gene between the locus DXPas4and the locus DXPas7defined by the cross-reacting human X chromosome-specific probe DXS32 (M2C). This localization on the mouse X chromosome is compatible with the presence of the A-rafoncogene on the short arm of the human X chromosome between the centromere and Xp21. |
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