| 全反式维甲酸对大鼠腹主动脉球囊损伤后血管重塑的影响 |
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| 引用本文： | 王卫民,党书毅,王家宁,黄永章,陈霞萍,刘志祥,周芳,张群林.全反式维甲酸对大鼠腹主动脉球囊损伤后血管重塑的影响[J].医学理论与实践,2001,14(10):954-956. |
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| 作者姓名： | 王卫民 党书毅 王家宁 黄永章 陈霞萍 刘志祥 周芳 张群林 |
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| 作者单位： | 1. 勋阳医学院分子生物学研究所,湖北,十堰,442000
2. 郧阳医学院附属太和医院心内科 |
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| 摘 要： | 目的:研究全反式维甲酸(ATRA)对球囊损伤大鼠腹主动脉血管重塑的影响。方法:制作球囊损伤的大鼠腹主动脉剥脱模型,12只Wistar大鼠随机分为①对照组:6只腹腔内注射intralipid(1mL/d),②ATRA组:6只腹腔内注射溶解于intralipid的ATRA(4mg·kg~(-1)·d~(-1)).球囊损伤14d后,损伤区域的血管段用10％福尔马林固定,然后染色,进行形态学分析。结果:ATRA明显减小新生内膜面积(IA),增加管腔面积(LA)和外弹力膜包绕面积(EEL)。结论:ATRA具有促进有益的血管重塑的作用。
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| 关 键 词： | 全反式维甲酸 血管重塑 平滑肌 血管 |
| 修稿时间： | 2001年4月29日 |
Effect of All-trans Retinoic Acid on Vascular Remodeling in Rat Abdominal Artery with Balloon Withdrawal Injury |
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| WANG Weimin,DANG Shuyi,WANG Jianing,HUANG Yongzhang,CHEN Xiaping,LIU Zhixiang,ZHOU Fang,ZHANG Qunlin.Effect of All-trans Retinoic Acid on Vascular Remodeling in Rat Abdominal Artery with Balloon Withdrawal Injury[J].The Journal of Medical Theory and Practice,2001,14(10):954-956. |
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| Authors: | WANG Weimin DANG Shuyi WANG Jianing HUANG Yongzhang CHEN Xiaping LIU Zhixiang ZHOU Fang ZHANG Qunlin |
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| Institution: | WANG Weimin1,DANG Shuyi2,WANG Jianing2,HUANG Yongzhang1,CHEN Xiaping1,LIU Zhixiang1,ZHOU Fang1,ZHANG Qunlin2. Institute of Life Sciences,Yunyang Medical College,Shiyan,Hubei 442000, 2 Department of Cardiology,Taihe Hospital,Yunyang Medical College. |
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| Abstract: | Objective: To investigate the effect of all- trans retinoic acid (ATRA)on vascular remodeling after balloon withdrawal injury in the rat abdominal artery.Methods:The rat denuded abdominal artery model with balloon withdrawal injury was performed. Twelve Wistar rats were randomly assigned to (1)Control group: intraperitoneal injection of intralipid( 1mL/d): (2) ATRA group: in-traperitoneal injection of ATRA dissolved in intralipid(4mg·kg-1·d-1) .Fourteen days after balloon withdrawal injury the in situ per-fusion fixation was performed with 10% formalin and the specimens were obtained. Morphometric analysis were performed. Results: ATRA significantly reduced neointimal area( IA) , increased lumen area (LA) and external elastic lamina atea( EEL). Conclusion: A-TRA has promoted favorable vascular remodeling of injured vascular. |
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| Keywords: | All-trans retinoic acid Vascular remodeling Smooth muscle Vascular |
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