子宫颈小细胞癌的临床及病理分析

目的 探讨子宫颈小细胞癌的临床病理特征诊断和治疗。方法 回顾性分析８例子宫颈小细胞癌的临床记录和随访资料。结果 ８例均表现为不同程度的阴道排液增多，病理学特点为大小形态一致的圆形或短梭形小细胞，弥漫性浸润间质，符事宫颈小细胞癌的病理学诊断；２例神经元特异性烯醇化酶免疫组织化学染色阳性，８例中，Ｉｂ期５例，Ⅱｂ期３例，７例接受了广泛子宫切除及盆腔淋巴结清扫描术治疗，１例Ⅱｂ期患者仅接受了放射治疗。２

Clinicopathologic Study of Patients with Small Cell Carcinoma of the Cervix

OBJECTIVE: To study the clinicopathologic characteristics, diagnosis and treatment of small cell carcinoma of the cervix. METHODS: Eight patients with small cell carcinoma of the cervix were treated from May 1991 to December 1997 at Jiangxi Women's and Children's Hospital. Clinical data and follow-up records were retrospectively analyzed. RESULTS: Five patients had stage I(b) disease and 3 had stage II(b) disease. Seven patients underwent radical hysterectomy with pelvic lymph node dissection. One patient with stage II(b) disease was only treated with radiotherapy. Of the patients treated with operation, three showed pelvic lymph node metastases. Four patients who are alive free of the disease have been followed for 2, 13, 16 and 25 months, respectively. The survival intervals of 4 patients who died of the disease was 4, 5, 7 and 10 months, respectively. Of the death, one patient was only treated with radiotherapy, another had a very large cervical tumor and the two others complicated with pelvic lymph node metastases. CONCLUSIONS: Small cell carcinoma of the cervix is an aggressive tumor with a potentiality for early pelvic lymph node metastases and rapid recurrence, It is associated with higher mortality than any other cervical malignant neoplasms. It is able to make a right diagnosis with a combination of histopathologic and immunohistochemical characteristics.