Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives |
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Authors: | Yoichi Nakazawa Makoto Kotorii Masachika Ohshima Shuichi Horikawa Hisayuki Tachibana |
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Affiliation: | (1) Department of Neuropsychiatry, School of Medicine, Kurume University, Japan |
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Abstract: | The effects of new thienodiazepine derivatives, such as clotiazepam and Y-7131, on normal human sleep were investigated on 5 subjects and compared to those of benzodiazepine derivatives, such as diazepam and nitrazepam. REM sleep was significantly decreased only with 2 mg of Y-7131 and rebound elevation of REM sleep did not follow in recovery 1 and 2 nights. By using partial differential REM deprivation which was designed by us, there was also no rebound elevation of REM sleep noted in recovery 2 night following 2 mg of Y-7131 medication. REM sleep was not suppressed with 15 mg of clotiazepam, 6 mg of diazepam and 10 mg of nitrazepam when compared to the baseline night. With regard to NREM sleep, stage 2 was significantly increased with 15 mg of clotiazepam and 10 mg of nitrazepam, but stage SWS was significantly decreased with 10 mg of nitrazepam. |
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Keywords: | Thienodiazepine derivative Benzodiazepine derivative Human REM sleep REM deprivation |
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