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树突状细胞表面特异性非整联蛋白外显子4在中国裔丙型肝炎患者中的遗传多态性
引用本文:王敏,王辉,蒋小玲,陆坚,詹雨林,韩红星,乐晓华,周伯平. 树突状细胞表面特异性非整联蛋白外显子4在中国裔丙型肝炎患者中的遗传多态性[J]. 中华肝脏病杂志, 2007, 15(12): 889-892
作者姓名:王敏  王辉  蒋小玲  陆坚  詹雨林  韩红星  乐晓华  周伯平
作者单位:1. 深圳市东湖医院肝病研究所,518020
2. 深圳市东湖医院科教科,518020
3. 深圳市龙岗中心医院
4. 深圳市东湖医院检验科,518020
基金项目:广东省医学科学技术研究基金(A2005628)
摘    要:目的探讨树突状细胞表面特异性非整联蛋白(DC—SIGN)及其同源物(DC-SIGNR)外显子4遗传多态性在中国裔丙型肝炎患者中是否存在遗传易感性。方法采用PCR结合DNA测序对300例丙型肝炎患者和520名健康人的DC-SIGN和DC-SIGNR外显子4重复序列多态性进行基因分型和测序分析。结果DC—SIGN外显子4基因型与等位基因频率在丙型肝炎患者和健康人群间差异无统计学意义(P〉0.05)。DC-SIGNR外显子4等位基因的频率差异也无统计学意义(P〉0.05);但9/5基因型分布频率在丙型肝炎患者和健康人群间的差异有统计学意义(P〈0.05)。结论DC-SIGN外显子4遗传多态性与HCV感染易感性无明显相关性;9/5基因型DC-SIGNR外显子4在丙型肝炎患者中的分布频率较高,可能与HCV感染的易感性相关,值得进一步研究。

关 键 词:肝炎  丙型 外显子 多态性 树突状细胞表面特异性非整联蛋白
收稿时间:2007-05-29

Genetic polymorphism of dendritic cell-specific ICAM-3 grabbing nonintegrin and DC-SIGNR''s exon 4 in Chinese hepatitis C patients
WANG Min,WANG Hui,JIANG Xiao-ling,LU Jian,ZHAN Yu-lin,HAN Hong-xing,LE Xiao-hua,ZHOU Bo-ping. Genetic polymorphism of dendritic cell-specific ICAM-3 grabbing nonintegrin and DC-SIGNR''s exon 4 in Chinese hepatitis C patients[J]. Chinese journal of hepatology, 2007, 15(12): 889-892
Authors:WANG Min  WANG Hui  JIANG Xiao-ling  LU Jian  ZHAN Yu-lin  HAN Hong-xing  LE Xiao-hua  ZHOU Bo-ping
Affiliation:Shenzhen Donghu Hospital, Shenzhen, China. xinyiwang001@yahoo.com.cn
Abstract:OBJECTIVE: To study into the genetic polymorphism of DC-SIGN and DC-SIGNR's exon 4 in Chinese hepatitis C patients and its relationship with HCV infection susceptibility. METHODS: Patients with hepatitis C (n=300, group A) and healthy subjects (n=520, group B) were genotyped and analysed for the repeat sequence of polymorphism of DC-SIGN and DC-SIGNR's exon 4 using PCR and DNA sequencing. RESULTS: The distribution of genotypes and alleles in DC-SIGN's exon 4 in the two groups did not differ significantly (P > 0.05). The difference of allele frequency in DC-SIGNR's exon 4 between the two groups was also not significant (P > 0.05). However, 9/5 genotype distribution frequency of DC-SIGNR's exon 4 in patients with hepatitis C was significantly higher than that in the healthy subjects (P < 0.05). CONCLUSION: There is no significant correlation between the genetic polymorphism of DC-SIGN's exon 4 and HCV infection susceptibility. 9/5 genotype distribution frequency of DC-SIGNR's exon 4 in patients with hepatitis C is significantly higher and may be associated with HCV infection susceptibility.
Keywords:Hepatitis C   Exons   Polymorphism   DC-specific ICAM-3 grabbing nonintegrin
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