Triplet repeat polymorphism in the transmembrane region of the MICA gene in celiac disease |
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Authors: | Fernandez L Fernandez-Arquero M Gual L Lazaro F Maluenda C Polanco I Figueredo M A Gomez de la Concha Emilio |
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Affiliation: | Deparment of immunology, San Carlos University Hospital, Madrid, Spain. |
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Abstract: | Celiac disease (CD) is characterized by a striking expansion of gamma delta T cells in the intestine. These cells interact with MICA, a cell surface protein encoded by a major histocompatibility complex gene. We investigated whether MICA gene polymorphism could contribute to susceptibility to CD. DNA typing for HLA-DR, DQA1, DQB1, TNF-308, TNFa, TNFb and a triplet repeat polymorphism in the transmembrane region of the MICA gene were carried out. We performed case-control stratified association studies and transmission disequilibrium tests. Our results indicate that although there is no primary association between MICA polymorphism and CD, there is, in addition to HLA-DQ, a second susceptibility locus on the 8.1 ancestral haplotype in strong linkage disequilibrium with MICA A5.1 allele. |
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Keywords: | celiac disease gene association HLA MICA |
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