Genetic recombination between malignant hyperthermia and calcium release channel in skeletal muscle |
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| Authors: | T. Fagerlund G. Islander E. Ranklov I. Harbltz J. G. Hange E. Mokleby K. Barg |
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| Affiliation: | Institute of Medical Genetics, University ot Oslo, Norway;Department of Anesthesiology, University of Lund, Sweden;Department of Biochemistry, Norwegian College of Veterinary Medicine, Oslo, Norway |
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| Abstract: | Absolute linkage between the gene, on chromosome 19, for the calcium release channel (CRC) of the sarcoplasmic reticulum in skeletal muscle and malignant hyperthermia (MH) has been reported by other workers. In the present study of three Swedish Families informative with respect to this linkage relationship, definite recombinants were found in two families. We conclude that mutations in other genes than the CRC gene can cause the clinical picture of MH. Accordingly, MH appears to be genetically heterogeneous. |
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| Keywords: | calcium release channel candidate genes genetics heterogeneity linkage malignant hyperthermia recombination |
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