| 聚乙烯吡咯烷酮K30对姜黄素的增溶作用研究 |
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| 引用本文： | 许东晖,王胜,梅雪婷,罗小菊,许实波.聚乙烯吡咯烷酮K30对姜黄素的增溶作用研究[J].中药材,2008,31(3):438-442. |
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| 作者姓名： | 许东晖 王胜 梅雪婷 罗小菊 许实波 |
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| 作者单位： | 中山大学生命科学院中药与海洋药物研究室,广东广州,510275 |
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| 摘 要： | 目的评价聚乙烯吡咯烷酮K30(PVP K30)对姜黄素的增溶作用.方法选择PVP K30作为载体,用溶剂法制备姜黄素固体分散体;通过差示扫描量热分析和X射线粉末衍射鉴别姜黄素在载体中的存在状态以及与载体之间的相互作用,并采用紫外-可见分光光度法测定姜黄素固体分散体的溶解度以及体外溶出度.结果紫外-可见分光光度法测定姜黄素的溶出量,利用PVP K30制备姜黄素固体分散体,与姜黄素本身相比,固体分散体中姜黄素溶解度提高了880倍以上,溶出速度明显增大.结论PVP K30可作为载体以提高姜黄素溶解度及溶出速度.
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| 关 键 词： | 姜黄素 PVP K30 固体分散体 溶解度 聚乙烯吡咯烷酮 姜黄素 增溶作用 研究 Curcumin Solubility Enhancement 溶出速度 利用 溶出量 结果 体外溶出度 溶解度 分光光度法测定 相互作用 状态 存在 鉴别 射线粉末衍射 扫描量热分析 差示 |
| 文章编号： | 1001-4454(2008)03-0438-05 |
| 修稿时间： | 2007年8月6日 |
Studies on Solubility Enhancement of Curcumin by Polyvinylpyrrolidione K30 |
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| XU Dong-hui,WANG Sheng,MEI Xue-ting,LUO Xiao-ju,XU Shi-bo.Studies on Solubility Enhancement of Curcumin by Polyvinylpyrrolidione K30[J].Jorunal of Chinese Medicinal Materials,2008,31(3):438-442. |
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| Authors: | XU Dong-hui WANG Sheng MEI Xue-ting LUO Xiao-ju XU Shi-bo |
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| Institution: | Laboratory of TCM and Marine Drugs, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. |
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| Abstract: | OBJECTIVE: To study solubility enhancement of curcumin by Polyvinylpyrrolidione K30 (PVP K30). METHODS: Solid dispersion systems (SDS) of curcumin in PVP K30 were prepared at various weight ratios by co-evaporation of curcumin and PVP K30 ethanol solution. The differential scanning calorimetry (DSC) and powder X-ray diffractometer method were used to describe the status of curcumin in carriers, the UV spectrometry method for determination of curcumin in mediums was established. RESULTS: The curcumin SDS was successfully prepared, the UV spectrometry method was accurate and reliable, and no interference occurred from carrier. The solubility rate in vitro of curcumin was significantly raised. Compared to curcumin, the solubility of curcumin in SDS increased at least 880 folds. CONCLUSION: PVP K30 improves the solubility of curcumin well. |
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