乳腺癌组织中PTEN蛋白的表达

目的 为阐明乳腺癌组织中PTEN蛋白表达改变的意义。方法 利用SP免疫组化技术检测PTEN蛋白在乳腺癌、不典型导管内上皮增生、正常乳腺组织的表达。结果 乳腺癌PTEN蛋白的阳性率和阳性强度低于正常乳腺（P＜0．01）和不典型导管内上皮增生组（P＜0．05）；表达强度与乳腺癌分化程度有关（P＜0．05），分化愈差，表达愈弱。不典型导管内上皮增生PTEN的表达比正常乳腺低（Ｐ＜0．05），较乳腺癌组织强（P＜0．05）。结论 通过检测PTEN的表达，对估计乳腺癌的预后有一定意义，可预测不典型导管内上皮增生发生癌变的可能性。

The Expression of PTEN Protein in Breast Carcinoma Tissues

Objective To elucidate the significance of expressive change in tissues of breast carcinomas.Methods Expression of PTEN protein was detected by immunohistochemistry (SP) in breast carcinomas?atypical intraductal hyperplasia?normal breast tissue. Results The positive rate and expressive intensity of PTEN protein in breast carcinoma were lower and weaker than those in atypical intraductal hyperplasia and normal breast. The intensity of PTEN protein expression was associated with differentiation degree of breast carcinoma, the poorer differentiation of breast carcinoma , the weaker expression of PTEN protein. Comparing with breast carcinoma, the PTEN expression level of atypical intraductal hyperplasia was higher , but It was lower than normal breast tissue. it is helpful for us to assess the carcinogenesis probability of atypical intraductal hyperplasia by detecting the PTEN.