系统性红斑狼疮性血管炎

系统性红斑狼疮(SLE)中最常累及的是皮肤小血管,也可累及多种内脏器官(如心血管、肺泡、胃肠道、肾小球、中枢神经系统及周围神经)的大、中血管,并引起坏死性损害,导致一系列系统症状的发生。免疫复合物和抗磷脂抗体可能与SLE性血管炎的发生具有密切关系。正确认识SLE性血管炎的发病机理及其所引起的临床表现,有利于疾病的早期诊断和治疗,可有效降低血管炎的发生率和SLE患者的死亡率。

Vasculitis in Systemic Lupus Erythematosis

Vasculitis in systemic lupus erythematosis (SLE) mostly affects cutaneous small vessels,and visceral medium-and large-vessels including the cardiovascular system,lung alveoli,gastrointestinal tract,renal glomeruli,central nervous system and peripheral nerves are also be involved,causing necrotizing lesions responsible for varied clinical manifestations. Immune complex and antiphospholipid antibody are involved in vasculitis pathogenesis. The recognition of disease manifestations due to vasculitis in SLE has important implications for early diagnosis and treatment,and may be critical to reduce morbidity and mortality.