CD4 memory T cells on trial: immunological memory without a memory T cell |
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Authors: | Bell Eric B Westermann Jürgen |
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Affiliation: | Faculty of Life Sciences, Immunology Section, University of Manchester, Manchester M13 9PT, UK. |
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Abstract: | Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting na?ve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines. |
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