NP与EP方案治疗晚期非小细胞肺癌的疗效比较

目的:观察和比较NP、EP二种不同化疗方案治疗晚期非小细胞肺癌（NSCLC）的疗效和毒副作用。方法:将31例晚期NSCLC患者随机分两组,观察组15例,接受NP方案治疗;对照组16例,接受EP方案治疗。观察各组的临床疗效、毒副反应并进行比较。结果:观察组有效率41.67％,对照组有效率25％,主要毒副反应为骨髓抑制,观察组白细胞下降Ⅰ度～Ⅱ度50％,Ⅲ度40 ％,Ⅳ度3％;对照组白细胞下降Ⅰ度～Ⅱ度64.70％,无Ⅲ度～Ⅳ度的改变。结论:治疗晚期NSCLC,NP方案疗效高于EP方案。毒副反应为骨髓抑制,NP方案虽高于EP方案,患者可以耐受。

To compare the efficacy of NP or EP regimen chemotherapy for far-advanced non-advanced

Objective To compare the efficacy and side effect of NP or EP regimen chemotherapy for far-advanced non-advanced (NSCLC). Method Thirty-one far-advanced NSCLC patients were divided into two groups. Study group (15 cases) were treated with NP regimen chemotherapy. Control group (16 cases) were treated with EP regimen chemotherapy. Results The effective rate of study group was 41.67 % , and control group was 25 % . The major toxing was bone marrow inhibited. Decline of white blood cell in study group were 50% of Ⅰ to Ⅱ degree, 40% Ⅲ degree and 3% Ⅳ degree. That of control group were 64.70 % of Ⅰ to Ⅱ degree, and no Ⅲ to Ⅳ degree white blood cell decline. Conclusion The efficacy with NP regiman chemotherapy higher than EP regimen for far-advanced NSCLC patients. The toxity was bone marrow inhibited. Though the toxity with NP regimen was move serious than EP regimen, the patients could endure.