| 光化学诱导脑缺血损害区NO和Ca^2＋的变化及绞股蓝总皂甙的保护作用 |
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| 引用本文： | 唐小卿 朱炳阳 陈剑雄 曹建国 黄红林 廖端芳 余麟. 光化学诱导脑缺血损害区NO和Ca^2＋的变化及绞股蓝总皂甙的保护作用[J]. 南华大学学报(医学版), 2001, 29(2): 113-115 |
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| 作者姓名： | 唐小卿 朱炳阳 陈剑雄 曹建国 黄红林 廖端芳 余麟 |
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| 作者单位： | 南华大学 药物药理研究所 |
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| 基金项目： | 湖南省自然科学基金资助课题：No:9420933湖南省教委资助课题，No:1191206 |
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| 摘 要： | 目的 探讨NO、Ca
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| 关 键 词： | 一氧化氮 钙超载 光化学反应 脑缺血 绞股蓝总皂甙 |
| 文章编号： | 1000-2510(2001)02-0113-03 |
| 修稿时间： | 2000-12-13 |
Protective Effect ofGypenosides on Ischemic Brain Damage Induced by Photochemistry |
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| TANG Xiao-qing. Protective Effect ofGypenosides on Ischemic Brain Damage Induced by Photochemistry[J]. Journal of Nanhua University(Medical Edition), 2001, 29(2): 113-115 |
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| Authors: | TANG Xiao-qing |
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| Abstract: | Aim:To study the effects of gypenosides on ischemic brain damage induced by photochemistry in rats. Methods:The rat modle of middle cerebral artery occlusion(MCAO)was induced by photochemistry.The contents of Ca 2+ ,H 2O and MDA,NO level and superoxide dismutase(SOD) activity were measured. Results:After MACO,cerebral ischemia was formed,NO level and SOD activity were decreased,the contents of H 2O,Ca 2+ and MDA were increased.Gyp could reduce the ischemic areas of brain and decrease contents of H 2O,Ca 2+ and MDA.Furthermore,Gyp also increased NO level and SOD activity of brain. Conclusion:Decrease of NO level and Ca-overload were important factors leading to ischemic brain damage.Gyp could protect ischemic brain damage by influencing pathological change of NO and Ca 2+ levels. |
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| Keywords: | nitric oxide Ca-overload photochemistry cerebral ischemia gypenosides |
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