| 生长激素对门静脉高压症病人肝蛋白质合成的影响 |
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| 引用本文： | 李为苏,吴性江,韩建明,黎介寿. 生长激素对门静脉高压症病人肝蛋白质合成的影响[J]. 肠外与肠内营养, 2004, 11(1): 23-25 |
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| 作者姓名： | 李为苏 吴性江 韩建明 黎介寿 |
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| 作者单位： | 南京军区南京总医院解放军普通外科研究所,江苏南京,210002;南京军区南京总医院解放军普通外科研究所,江苏南京,210002;南京军区南京总医院解放军普通外科研究所,江苏南京,210002;南京军区南京总医院解放军普通外科研究所,江苏南京,210002 |
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| 摘 要： | 目的:了解生长激素(GH)对经颈静脉肝内门体分流术(TIPS)后门脉性肝硬化病人肝蛋白质代谢的影响. 方法:对10例门静脉高压症病人,在TIPS术后第2天开始皮下注射重组人生长激素(rhGH)8 U×7天.检测治疗前及治疗后3、7天血清清蛋白(Alb)、前清蛋白(PA)、纤维连接蛋白(FN)水平,同时测定血清胰岛素样生长因子(IGF-1)水平,进行治疗前后的比较. 结果:血清IGF-1水平TIPS术前与术后比较无显著差异,GH治疗后3天明显升高(P<0.01);Alb水平TIPS术前与GH治疗后3天比较无显著差异,7天后明显升高(P<0.05);PA和FN水平在GH治疗后第3天开始升高,第7天明显升高 (P<0.01). 结论:GH可以促进肝硬化门静脉高压症病人肝蛋白质合成.
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| 关 键 词： | 肝硬化 门静脉高压症 生长激素 蛋白质代谢 |
| 文章编号： | 1007-810X(2004)01-0023-02 |
| 修稿时间： | 2003-10-28 |
Effect of growth hormone on liver protein synthesis in patients with portal hypertension |
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| LI Wei su,WU Xing jiang,HAN Jian ming,LI Jie shou. Effect of growth hormone on liver protein synthesis in patients with portal hypertension[J]. Parenteral & Enteral Nutrition, 2004, 11(1): 23-25 |
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| Authors: | LI Wei su WU Xing jiang HAN Jian ming LI Jie shou |
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| Abstract: | Objectives: To investigate the effect of growth hormone on liver protein synthesis in patients with portal hypertension following TIPS. Methods: Ten patients with liver cirrhosis and portal hypertension were injected with rhGH (8 U/day) for 7days after TIPS. The serum levels of Alb, PA and FN were detected before and days 3 and 7 after TIPS and use of rhGH. Plasma insulin like growth factor 1 (IGF 1) was also measured by immunoradiological method. Results: As compared with the day before TIPS and rhGH, the levels of IGF 1, Alb , PA and FN were significantly increased on the 7th day after TIPS and rhGH treatment( P <0.01). Conclusions: The rhGH treatment after TIPS can facilitate liver protein synthesis in patients with liver cirrhosis and portal hypertension. |
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| Keywords: | Liver cirrhosis Portal hypertension Growth hormone Protein metabolism |
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