促红细胞生成素在子宫内膜异位症组织中的表达及意义

目的探讨促红细胞生成素(Epo)在子宫内膜异位症(Ems)发生发展中的作用及其临床意义。方法采用免疫组织化学SP法,分别检测Epo在30例子宫内膜异位症患者的异位内膜、在位内膜及30例非子宫内膜异位症患者正常内膜组织中的表达。结果Epo染色阳性细胞主要集中于腺上皮细胞的胞浆中,周围间质细胞无明显着色。异位内膜和在位内膜的表达明显高于正常内膜(P<0.01);异位内膜和在位内膜的表达差异无统计学意义(P>0.05);增生期和分泌期比较,差异无统计学意义(P>0.05)。结论Epo可能在子宫内膜异位症的发生发展中起着重要作用。

Expression and significance of erythropoietin in endometriosis tissues

Objective To investigate the expression of erythropoietin(Epo) in endometriosis and its related clinical roles.Methods Both ectopic and eutopic endometrial tissues were collected from 30 cases of endometriosis,and the normal endometrial tissues were collected from 30 cases of non endometriosis.The expression of Epo was examined by SP immunohistochemistry.Results The expression of Epo predominately concentrated in cytoplasm of glandular epithelial cells,while there was no obvious expression in stromal cells.Epo expressions in both ectopic endometrium and eutopic endometrium were higher than those of normal endometrium(P<0.01),but there was no significant difference between the ectopic endometrium and eutopic endometrium(P>0.05).In addition,there was no significant difference in the expression of Epo between the proliferative phase and secretory phase in three groups(P>0.05).Conclusion Epo may play an important role in the progression of endometrosis.