Varioliform mucosal polypoid lesions in intestinal tract in a patient with adult T-cell leukemia |
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Authors: | Izuru Gakiya Yukino Kugai Shokita Hayashi Seishou Nimura Osamu Zaha Akihiko Kouchi Junichi Oshiro Hiroshi Sakugawa Keizo Kitukawa Fukunori Kinjou Atushi Saitou Kouichi Araki |
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Institution: | (1) First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara-cho 207, 903-01 Okinawa, Japan;(2) Department of Preventive Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara-cho 207, 903-01 Okinawa, Japan |
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Abstract: | We describe a case of adult T-cell leukemia (ATL) with intestinal infiltration. In the early clinical stage, the endoscopic
findings for the intestine were similar to those of amebic enterocolitis, i.e., varioliform mucosal polypoid lesions, and
amebic cyst was detected with stool examination. Although no specific pathological factor could be identified on biopsy, the
patient was treated for amebiasis as a diagnostic therapy. the findings of varioliform mucosal polypoid lesions were detected
in the duodenum on endoscopic examination, but the lesions eventually disappeared during the treatment for amebiasis. We then
suspected lymphoma partially masked by, the amebiasis. Immunological staining of a specimen of the colonic mucosa revealed
T cell invasion and Southern blotting demonstrated adult T-cell leukemia provirus invasion. Thus, ATL cell infiltration of
the intestinal tract was confirmed It is suggested that systemic disease should also be considered when varioliform mucosal
polypoid lesions are found on colonoscopic examination. |
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Keywords: | varioliform mucosal polypoid lesion adult T-cell leukemia amebiasis Southern blotting |
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