雌激素与缺血性心脏病

以往的临床观察证实 ,生育年龄的女性缺血性心脏病的发病率和死亡率明显低于同龄男性。绝经后的妇女服用雌激素与不服用雌激素相比 ,前者心脏病事件少于后者。尽管临床的观察结果还有争议 ,越来越多的临床前期研究表明 ,雌激素对缺血性心脏病具有保护作用。研究结果显示 ,雌激素和其受体调节器是通过减少炎性反应在缺血/再灌注引起心肌损伤时起保护作用的。本文作者就近年的一些研究结果作一综述 ,并就雌激素替代治疗处理心肌缺血及再灌注损伤进行探讨。

Estrogen and ischemic heart disease

Prospective clinical observations have suggested that morbidity and mortality of ischemic heart disease in premenopausal women is lower than age-matched men. Exogenous administration of estrogen to postmenopausal women has shown the beneficial effects for reducing cardiovascular events over time compared with untreated women. Although there is still controversy for the final outcomes in clinical trial, a growing body of evidence from pre-clinical studies has demonstrated protective effects of estrogen on ischemic heart disease. This review summarizes the recent data that show protection by estrogen and its receptor modulators in attenuation of inflammation-mediated myocardial injury especially during reperfusion after ischemia. Potential future directions for using estrogen replacement therapy in treatment of heart ischemia and reperfusion injury are also discussed.