睡眠呼吸暂停综合征与高血压的相关性研究

目的:探讨睡眠呼吸暂停综合征(SAS)与高血压之间的关系及其形成机制。方法:比较54例SAS患者和54例对照者一般睡眠打鼾者高血压的发病率和睡前、醒后收缩压、舒张压,并将睡前、醒后收缩压、舒张压与睡眠呼吸暂停低通气指数(AHI)、夜间最低SaO2(SaO2-min)进行相关分析。结果:SAS组合并高血压的发病率高于对照组。SAS组醒后的收缩压和舒张压均较睡前增高,对照组醒后的收缩压和舒张压较睡前均无明显变化。SAS患者睡前及醒后SBP、DBP与AHI均呈正相关,睡前DBP与SaO2-min呈负相关,且前四个相关系数绝对值均较后者大,而睡前SBP、醒后SBP及DBP与SaO2-min无显著相关。结论:SAS与高血压相关,且是高血压的一个独立危险因素。缺氧可能不是SAS合并高血压的主要机制。

Study on the Correlation between Sleep Apnea Syndrome and Hypertension

Objective: To explore the correlation between sleep apnea syndrome(SAS) and hypertension,and the pathogeny of hypertension as a result of SAS. Methods: The incidence of hypertension,pre-sleep systolic blood pressure(SBP) and diastolic blood pressure(DBP) and post-sleep SBP and DBP were compared between 54 cases of SAS and 54 cases in the control group,and the correlations were analyzed between pre-sleep and post-sleep SBP,DBP and AHI and lowest arterial oxygen saturation(SaO_2~-min).Results: The incidence of hypertension as a complication of SAS in the SAS group was higher than that in the control group.The post-sleep SBP and DBP were higher than pre-sleep SBP and DBP in the SAS group,while there were no significant differences in the control group.The pre-sleep and post-sleep SBP and DBP were positively correlated with AHI,and pre-sleep DBP was negatively correlated with SaO_2~-min.The absolute values of the correlation confficients of the former correlations were higher than that of the latter.There were no significant correlations between pre-sleep SBP,post-sleep SBP,post-sleep DBP and SaO_2~-min.Conclusion: SAS is correlated with hypertension and is an independent risk factor for hypertension.Hypoxia might not be the major pathogeny of hypertension in SAS patients.