妊高征患者内皮素、一氧化氮测定的临床意义

目的：了解内皮素、一氧化氮在妊高征发病中的作用。方法：放射免疫分析法检测了３９例妊高征患者、２８例正常晚孕妇女产前及产后血浆遥含量，同时采用ｒｅｉｓｓ法测定亚硝酸盐及硝酸盐以间接测定ＮＯ含量。结果：妊高征２产前ＥＴ较正常妊高征组明显升高，ＮＯ则明显下降（均Ｐ〈０．０１），且与妊高征病情程度有一定关系，产后逐渐恢复正常。结论：妊高征患者血管内皮细胞存在内分泌功能紊乱，ＥＴ合成释放增加，ＮＯ释放减少，

The Clinical Significance of Determination of Plasma Endothelin, Nitric Oxide in Patients with Pregnancy Induced Hypertension

Objective In order to study the role of plasma ET, NO in the cause of pregnancy induced hypertension (PIH).Methods The concentrations of plasma ET was detected by radioimmunoassay in 39 patients with PIH and 28 normal pregnant women. Meantime, plasma NO2/NO3 levels, the stable metabolic end product of NO was determined with Greiss determination. Rusults The antepartum plasma ET levels in patients with PIH were significantly higher than those in normal pregnancy (P<0.01), plasma NO levels were decreased markly (P<0.01). The score index of PIH had significant correlation with the levels of plasma ET, NO. And returned to non-pregnant status in postpartum period. Conclusion The functional changes of vessel endothelial cells in patients with PIH, and the inblance of endothelial relaxing and contracting factors might play an important part inthe pathogenesis of PIH.