Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder |
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| Authors: | Murat Demirta? Cristian Tornador Carles Falcón Marina López‐Solà Rosa Hernández‐Ribas Jesús Pujol José M Menchón Petra Ritter Narcis Cardoner Carles Soriano‐Mas Gustavo Deco |
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| Institution: | 1. Department of Information and Communication Technologies, Center for Brain and Cognition, Universitat Pompeu Fabra, Barcelona, Spain;2. BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain;3. CIBER‐BBN, Barcelona, Spain;4. Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado;5. MRI Research Unit, CRC Mar, Hospital del Mar, Barcelona, Spain;6. Carlos III Health Institute, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain;7. Psychiatry Department, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain;8. Department of Radiology, MRI Research Unit, Hospital del Mar, Barcelona, Spain;9. Department of Clinical Sciences, University of Barcelona, Barcelona, Spain;10. Max‐Planck Institute for Cognitive and Brain Sciences, Leipzig, Germany;11. Department of Neurology, Charité, Berlin, Germany;12. Mental Health Department, Depression and Anxiety Program, Parc Taulí Sabadell, Barcelona, Spain;13. Hospital Universitari Department of Psychiatry and Legal Medicine, Universitat Autònoma De Barcelona, Spain;14. Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma De Barcelona, Spain;15. Institució Catalana de Recerca i Estudis Avan?ats, Barcelona, Spain |
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| Abstract: | Resting‐state fMRI (RS‐fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS‐fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self‐referential thoughts and ruminations has made the use of the resting‐state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS‐fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network. Hum Brain Mapp 37:2918–2930, 2016. © 2016 Wiley Periodicals, Inc. |
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| Keywords: | mood disorders major depressive disorder dynamic functional connectivity resting state fMRI |
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