| 妊娠滋养细胞肿瘤中细胞凋亡原位观察 |
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| 引用本文： | 胡建功,宋立刚,金小平,申兴斌,敖亚洲,王宁,王竹君. 妊娠滋养细胞肿瘤中细胞凋亡原位观察[J]. 承德医学院学报, 2006, 23(4): 353-355 |
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| 作者姓名： | 胡建功 宋立刚 金小平 申兴斌 敖亚洲 王宁 王竹君 |
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| 作者单位： | 承德医学院附属医院病理科,河北,承德,067000;承德医学院附属医院病理科,河北,承德,067000;承德医学院附属医院病理科,河北,承德,067000;承德医学院附属医院病理科,河北,承德,067000;承德医学院附属医院病理科,河北,承德,067000;承德医学院附属医院病理科,河北,承德,067000;承德医学院附属医院病理科,河北,承德,067000 |
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| 摘 要： | 目的:探讨妊娠滋养细胞肿瘤(GTT)中的细胞凋亡情况.方法:采用核酸原位末端标记(TUNEL)法,检测10例正常早期绒毛(NP)、10例完全性葡萄胎(CM)、20例侵袭性葡萄胎(IM)、19例绒癌(CCA)中的细胞凋亡.结果:在NP、CM、IM和CCA中,细胞凋亡指数(AI)分别为1.88%、2.59%、6.45%、1.26%,各组间差异有统计学意义,(F=7.020,P=0.000).其中,在IM与CCA之间,差异有统计学意义(P=0.009).结论:GTT的发生是由于机体监控能力减弱或消失、增殖与凋亡调节系统失调所致.
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| 关 键 词： | 妊娠滋养细胞肿瘤 细胞凋亡 TUNEL |
| 文章编号： | 1004-6879（2006）04-0353-03 |
| 收稿时间： | 2006-08-17 |
| 修稿时间： | 2006-08-17 |
A SURVEY IN SITE ON APOPTOSIS IN GESTATIONAL TROPHOBLASTIC TUMOR |
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| HU Jian-gong, SONG Li-gang, JIN Xiao-ping, et al. A SURVEY IN SITE ON APOPTOSIS IN GESTATIONAL TROPHOBLASTIC TUMOR[J]. Journal of Chengde Medical College, 2006, 23(4): 353-355 |
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| Authors: | HU Jian-gong SONG Li-gang JIN Xiao-ping et al |
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| Affiliation: | Department of Pathology, Affilicated hospital of Chengde Medecal college, Hebei Chengde 067000,China |
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| Abstract: | Objective:To investigate the apoptosis in gestational trophoblastic tumor(GTT).Methods:10 cases of normal placenta,10 cases of complete hydatidiform mole(CM),20 cases of invasive hydatidiform mole(IM) and 19 cases of choriocarcinoma(CCA) paraffin-embedded tissues were measured by terminal deoxy-nucleotidyl transferase-mediated dUTP-biotin nick end labeling(TUNEL).Results:In NP,CM,IM and CCA,the apoptosis index(AI) was 1.88%,2.59%,6.45% and 1.26% respectively with significant difference among them(F=7.020,P=0.000).There were significant difference between IM and CCA(P=0.009).Conclusion:The process of GTT is associated with trophoblastic cell overproliferation because the proliferation and apoptosis are out of control. |
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| Keywords: | TUNEL |
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