老年2型糖尿病人记忆损伤特点

目的　探讨年轻老年 2型糖尿病病人记忆是否受到损伤。方法　病人和对照各 30人 ,控制年龄 (65～ 85岁 ,平均 73岁 )、教育水平和相关疾病等因素。测试数字符号、数字工作记忆广度、动作记忆和无意义图形再认。结果　病人组一位数和二位数数字工作记忆广度、符号测试成绩无显著差异 ;病人组演练 /高语义关联项目和无演练 /低语义关联项目的自由回忆成绩显著低于对照组 ;线索回忆成绩无显著差异。结论　 65～ 85岁2型糖尿病病人记忆损伤既有加速老化的一面 ,也有特异性损伤的一面 ,记忆损伤在自由回忆条件下容易表现出来 ,并且动作记忆表现出特异性损伤。

Memory impairment in aged patients with typer 2 diabetes

Objective To explore whether type 2 diabetes (NIDDM) is associated with the impairment of memory function in the elderly. Methods 30 patients with type 2 diabetes and 30 controls, controlling age (65~85), education level, relative disease and other factors, which is likely to affect cognitive function, participated the study. Four types of cognitive tasks, including recognition of meaningless figures, digital symbol substitute, action memory (subject performed task) and mental arithmetic (digital span), which assessed different levels and aspects of memory function and were found sensitive to aging process to different extent, were administered. Results After multivariate adjustment, NIDDM patients displayed no difference on performances of digital symbol, meaningless figures and mental arithmetic. Action memory experiments show an experimental dissociation, which both free recall of well-integrated items with enactment support and poor-integrated items without enactment were affected by NIDDM; while cued recall performances revealed no difference compared with those of control subjects. Conclusions Cognitive impairments in type 2 diabetes patients were associated with normal aging and impaired action memory, which characterized the pathological dysfunction specifically.