| 脂肪肝患者A-FABP与胰岛素抵抗关系 |
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| 引用本文： | 张宝,蒋建华,肖永康,李秋桂,马泰. 脂肪肝患者A-FABP与胰岛素抵抗关系[J]. 中国公共卫生, 2010, 26(5) |
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| 作者姓名： | 张宝 蒋建华 肖永康 李秋桂 马泰 |
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| 作者单位： | 安徽医科大学第一附属医院营养部,合肥,230022 |
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| 摘 要： | 目的探讨非酒精性脂肪肝病(NAFLD)患者血清脂肪细胞型脂肪酸结合蛋白(A-FABP)与胰岛素抵抗(IR)的关系。方法选择NAFLD患者119例,正常对照120人,测量身高、体重、腰围、臀围、体质指数及腰臀比,检测血清中总胆固醇、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、空腹胰岛素抵抗指数及脂肪细胞型脂肪酸结合蛋白,并进行对比分析。结果NAFLD组血清A-FABP水平(13.45±5.06),明显高于对照组(9.14±5.00)μg/L(P0.01);且血清A-FABP水平与体质指数(BMI)、腰围(WC)、腰臀比(WHR)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、空腹胰岛素(FINS)、空腹血糖(FPG)及胰岛素抵抗指数(HOMA-IR)呈正相关(r依次分别为0.560,0.538,0.384,0.426,0.341,0.302,0.345,0.256,0.359,P均0.01),而与HDL-C呈负相关(r=-0.337,P0.001)。结论NAFLD患者存在胰岛素抵抗,且血清A-FABP水平与胰岛素抵抗密切相关。
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| 关 键 词： | 非酒精性脂肪肝 脂肪细胞型脂肪酸结合蛋白 胰岛素抵抗 |
Relationship between adipocyte fatty acid-binding protein and insulin resistance in patients with fatty liver |
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| ZHANG Bao,JIANG Jian-hua,XIAO Yong-kang,et al.. Relationship between adipocyte fatty acid-binding protein and insulin resistance in patients with fatty liver[J]. Chinese Journal of Public Health, 2010, 26(5) |
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| Authors: | ZHANG Bao JIANG Jian-hua XIAO Yong-kang et al. |
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| Affiliation: | ZHANG Bao,JIANG Jian-hua,XIAO Yong-kang,et al.Department of Nutriology,the Frist Affiliated Hospital,Anhui Medical University(Hefei 230022,China) |
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| Abstract: | Objective To study the relationship between adipocyte fatty acid-binding protein(A-FABP) and insulin resistance in patients with nonalcoholic fatty liver.Methods Overall 119 patients with nonalcoholic fatty liver and 120 normal controls were choosed.Hight,weight,waist circumference(WC),hip circumference,body mass index(BMI),waist-to-hip ratio(WHR),triglyceride,total cholesterol(TG),high density lipoprotein,fasting blood glucose(FBG),fasting blood insulin(FINS),homeostasis model assessment-insulin resistant ... |
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| Keywords: | nonalcoholic fatty liever adipocyte fatty acid-binding protein insulin resistant |
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