升解通瘀汤对大鼠心脏缺血再灌注损伤的心功能影响

目的 探讨升解通瘀汤对心脏缺血再灌注损伤心功能的影响。方法 大鼠随机分为假手术组、模型组、中药组（升解通瘀汤组）、西药组（倍他乐克组）和中西药组（升解通瘀汤十倍他乐克组），并予相应处理。生理仪记录缺血期以及复灌期左室内压最大变化速率（±dp／dt max），左室舒张末期压（LVEDP）及左室收缩末期压（LVSP）；心肌染色测定缺血面积和梗死面积百分比。结果预防性口服升解通瘀汤可以降低心肌梗死面积，升高心肌缺血再灌注损伤的LVSP和＋dp／dt max，降低INEDP和-dp／dt max，进而改善心肌血供。结论升解通瘀汤对大鼠心脏缺血再灌注损伤具有心肌保护作用。

Effect of Shengjietongyu Tang on Heart Function of Rat with Ischemia-reperfusion Injury

Objective： To determine the effect of Shengjietongyu Tang（STT） in protecting the heart of SD rats from ischemia - reperfusion injury （IRI） after induced ischemic event. Method： SD rats post induced myocardial ischemia-reperfusion injury models. 35 SD rats were divided into 5 groups： sham group, model group, Chinese medicine treatment group （STT treatment group）, western medicine treatment group （Metoprolol treatment group）, and Chinese -Westetla combination treatment group（STT- Metoprolol treatment group）. ＋ dp/dt max, LVEDP and LVSP of the left ventricle during the procedure were recorded. The heart was stained with TTC and photograph was taken to measure the ischenlic area. Result： Pre - treatment of STT was shown to reduce myocardial infarct area： simultaneously increase coronary circulation （by increasing LVSP and ＋ dp/dt max, and decrease LVEDP）. Conclusion： pre - treatment of STT has been shown to protect the heart fitllowing myocardial ischemia - reperfusion injury in SD rats.