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Preliminary experience with interactive guided brain biopsies using a vertically opened 0.5-T MR system
Authors:J-P Schneider  J Dietrich  S Lieberenz  F Schmidt  O Sorge  C Trantakis  V Seifert  S Kellermann  R Schober  P Franke
Institution:(1) Department of Diagnostic Radiology, University of Leipzig, Liebigstrasse 20 a, D-04103 Leipzig, Germany, DE;(2) Department of Neurosurgery, University of Leipzig, Liebigstrasse 20 a, D-04103 Leipzig, Germany, DE;(3) Department of Neuropathology, University of Leipzig, Liebigstrasse 20 a, D-04103 Leipzig, Germany, DE;(4) Technical Department/Medical Engineering, University of Leipzig, Liebigstrasse 20 a, D-04103 Leipzig, Germany, DE
Abstract:The purpose of our study was to evaluate the feasibility and accuracy of brain biopsies performed within a vertically opened MR system. We worked with the interventional 0.5-T MR “SIGNA SP” (General Electric Medical Systems, Milwaukee, Wis.) with an integrated tracking device “Flashpoint Position Encoder” (Image Guided Technologies, USA). As a holding device for this instrument we constructed a special frame. The whole system allows an exact adjustment of an optimum biopsy direction and guidance of the biopsy in a non-stereotactic, interactive mode in near real-time. As biopsy tools we used MR-compatible aspiration and specially made side-cut needles (Daum, Germany; E-Z-EM, USA). We performed a prospective diagnostic brain biopsy study in 18 patients. Guidance of the needle was carried out using gradient-echo single-slice technique. The sample was taken after controlling the exact position of the needle tip on spin-echo images. In 12 cases an exact neuropathological diagnosis was possible. In 6 cases of negative biopsy (4 aspiration biopsies) the samples were not representative. Our results demonstrate the feasibility of interactive MR-guided minimally invasive brain biopsies in an open MR system. The best results were achieved using cut needles for biopsies of contrast-enhancing lesions visible on T1-weighted gradient-echo guidance sequence. Received: 2 February 1998; Revision received: 13 July 1998; Accepted: 2 September 1998
Keywords:: Interventional MRI  Diagnostic brain biopsy
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