Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain |
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| Authors: | Junying Wang Junling Liu Shuping Chen Yonghui Gao Fanying Meng Lina Qiao |
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| Institution: | Junying Wang, Junling Liu, Shuping Chen, Yonghui Gao, Fanying Meng, Lina Qiao Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. The effects of electroacupuncture increased with prolonged time, but the above-mentioned effects decreased in memory-deficient animals. Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory. |
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| Keywords: | acetylcholinesterase chronic pain cumulative effect electroacupuncture analgesia hippocampus M1R mRNA expression vesicular acetylcholine transporter |
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