噻萘普订与丙咪嗪治疗抑郁症对照研究

目的：观察噻萘普汀治疗抑郁症的疗效和安全性。方法：随机将60例抑郁症患分为噻萘普汀组（30例）和丙咪嗪组（30例），疗程6周，采用汉密尔顿抑郁量表（HAMD）和副反应量表（TESS）在治疗前和治疗后1、2、4、6周末评定药物疗效和副反应。结果：两组疗效无显差异，HAMD总分及各因子分从治疗后2周至6周均较治疗前显降低，两组间无显性差异。治疗结束时TESS评分噻萘普汀组显低于丙咪嗪组。结论：噻萘普汀治疗抑郁症疗效好，副反应少，服用方便、安全，可首选使用。

A control study of Tianeptine and imipramine in the treatment of depression

Objective:To study the efficacy and safety of tainol in the treatment of depression Method:60 depressed patients were randomized into tianeptine group(n=30), imipramine(n=30) and studied for 6 weeks HAMD and TESS were used to assess the efficacy and side effects before and l week,2 weeks,4 weeks and 6 weeks after the treatment Result:There was no significant difference in efficacy between the two groups HAMD scores and the factor scores from week 2 to week 6 decreased dramatically as compared to pretreatment,no significant difference was observed between the two groups After the trial the TESS scores in tianeptine group were significantly lower than that of imipramine group Conclusion:tianeptine was an effective,convenient and safe treatment in depression It had few side effects and can be a first drug choice