| VEGF与卵巢癌的研究进展 |
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| 引用本文： | 宁尼亚,刘松凡.VEGF与卵巢癌的研究进展[J].中国当代医药,2014,0(22):186-188. |
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| 作者姓名： | 宁尼亚 刘松凡 |
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| 作者单位： | 宁尼亚 (河南省漯河市召陵区人民医院妇产科,河南漯河,462000)； 刘松凡 (河南省漯河市召陵区人民医院妇产科,河南漯河,462000)； |
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| 基金项目： | 河南省漯河市科技进步一等奖(项目编号：2011233) |
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| 摘 要： | 血管内皮生长因子（VEGF）及其受体在卵巢癌高表达，与卵巢癌的发生、发展、转移和预后等密切相关。VEGF受体不仅有酪氨酸激酶活性，而且可刺激血管内皮的分裂、增殖，促进肿瘤血管的生成，提高微血管的通透性，加快肿瘤细胞与血管内营养物质的交换，促进肿瘤的发生、发展。
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| 关 键 词： | 血管内皮生长因子 血管生成抑制剂 卵巢癌 |
Research progress on VEGF and ovarian cancer |
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| Authors: | NING Ni-ya LIU Song-fan |
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| Institution: | ( Department of Obstetrics and Gynecology,People＇s Hospital of Shaoling District of Luohe City in Henan Province,Luohe 462000,China) |
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| Abstract: | Vascular endothelial growth factor （VEGF）is a highly specific mitogen for vascular endothelial cells.It po-tentiates angiogenesis and promotes the vascular permeability.Strong expression of VEGF and its receptor has been found in various solid tumor types,including ovarian carcinoma.VEGF receptor not only has tyrosine kinase activity,but also can stimulate endothelial division,proliferation,promote angiogenesis,improve microvascular permeability,accelerate the exchange of nutrients tumor cells and blood vessels,promoting the development of tumor. |
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| Keywords: | Vascular endothelial growth factor Angiogenes inhibitor Ovarian cancer |
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