不同水质对小鼠脏器系数及血糖影响的研究

目的：初步探讨不同饮用水对小鼠脏器系数及血糖水平的影响。方法分别测定纯净水、自来水、净化水、高偏硅酸天然矿泉水的偏硅酸含量。将80只ICR小鼠随机分为4组,每组各20只,雌雄各半,分别用纯净水（对照组）、自来水、净化水和矿泉水喂养,90 d后眼球取血,测定空腹血糖值及小鼠体重、脏器系数。结果4种饮用水的偏硅酸含量差异有统计学意义（P〈0.05）,含量高低依次为纯净水〈净化水〈自来水〈矿泉水。与纯净水组比较,净化水组的小鼠心脏系数明显降低（P〈0.05）；矿泉水组雌性小鼠的空腹血糖水平也明显降低（P〈0.05）。结论不同水质可能对小鼠心脏系数及雌性小鼠血糖代谢有影响。

Effect of different water quality on organ coefficent and blood glucose in mice

Objective To explore the effect of different drinking water on organ coefficent and blood glucose in mice. Methods Metasilicic acid content was measured in the pure water,tap water,filtered tap-water and high metasilicate mineral water respectively.80 ICR mice （half male and half female） were randomly divided into the four groups and fed with pure water （the control group）,tap water,filtered tap-water and mineral water respectively.After 90 days, blood samples were taken from the eyeballs of mice. Then the fasting blood glucose,body weight and organ coefficient were analyzed. Results Metasilicic acid content of four kinds of drinking water had a statistical difference （P〈0.05）, which were pure water〈filtered tap-water〈tap water〈mineral water.Compared with the control group,a significant decline in cardiac coefficient of mice was observed in filtered tap-water group （P〈0.05）,and the same significant decline in fasting blood glucose of female mice was observed in the mineral water group （P〈0.05）. Conclusion Different water quality may cause biological effects on cardiac coefficient of mice and glucose metabolism in female mice.