氨溴索不同用法辅助治疗小儿肺炎的临床效果观察

目的：探讨氨溴索辅助治疗小儿肺炎的临床应用效果。方法选取本院2010年1月∽2014年1月收治的200例小儿肺炎患者，随机分为对照组、观察A组、观察B组、观察C组，每组50例，对照组患儿采用常规治疗，观察A组患儿在常规治疗的基础上辅助采用氨溴索雾化进行治疗，观察B组患儿在常规治疗基础上辅助采用氨溴索静脉滴注进行治疗，观察C组患儿在常规治疗基础上行氨溴索静脉滴注＋雾化进行治疗。观察4组的治疗效果。结果观察A组治愈37例（74%），观察B组治愈36例（72%），观察C组治愈42例（84%），对照组治愈26例（52%），观察组3组的治愈率明显高于对照组（P〈0.05）；观察C组的总有效率明显高于观察A组、观察B组（P〈0.05）。观察组3组患儿的体温恢复正常时间、咳嗽咳痰时间、肺部体征消失时间及住院时间均明显短于对照组，差异有统计学意义（P〈0.05）；观察A组和观察B组间差异无统计学意义（P〉0.05），观察C组与观察A组、观察B组比较，差异有统计学意义（P〈0.05）。结论利用氨溴索辅助治疗小儿肺炎能有效改善患儿的临床症状，缩短患儿住院时间，其中，采用氨溴索静脉滴注＋雾化治疗的方式能进一步缩短治疗时间，减轻患儿痛苦，治疗效果更加明显，值得临床推广应用。

Clinical effect observation on different usages of ambroxol as adjuvant therapy for children with pneumonia

Objective To investigate the clinical effect of ambroxol in adjuvant treatment of children with pneumonia. Methods Two hundred cases of patients with pediatric pneumonia in our hospital from January 2010 to January 2014 were included in this study,and were randomly divided into control group,observation group A,observation group B and observation group C,50 cases in each group.Patients in control group were treated with conventional therapy,patients in observation group A were treated with atomized ambroxol,patients in observation group B were treated with intravenous-ly ambroxol,patients in observation group C were treated with both atomized and intravenously ambroxol.The effects in four groups were observed. Results There were 38 cases （76%） cured in observation group A and 36 cases （72%） in observation group B,42 cases （84%） in observation group C,and 26 cases （52%） in control group,the cure rate of three observation groups was higher than that of control group （P〈0.05）.The total effective rate in observation group C was higher than that in observation group A and observation group B （P〈0.05）.In observation group A,B and C,the time of body temperature returning to normal,cough and expectoration,pulmonary symptoms disappearing and the period of hos-pital stay were all shorter than those in control group,the differences were significant （P〈0.05）.There was no significant difference between observation group A and B （P〉0.05）,while the observation group C compared with observation group A and B,the difference was significant （P〈0.05）. Conclusion The use of ambroxol as an adjuvant therapy for children with pneumonia can improve the clinical symptoms effectively,and shorten patient’s time of hospitalization.Meanwhile, the combination of ambroxol by intravenous and atomization can further reduce the treatment time and relieve symp-toms,showing more effective.Hence,it is worthy of expansion in clinic.