Dietary acrylamide intake and risk of colorectal cancer in a prospective cohort of men |
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| Authors: | Susanna C. Larsson Agneta Åkesson Leif Bergkvist Alicja Wolk |
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| Affiliation: | 1. Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, P.O. Box 210, SE-17177 Stockholm, Sweden;2. Department of Surgery and Centre for Clinical Research, Central Hospital, Västerås, Sweden;1. School of Arts and Sciences, Department of Natural Sciences, Lebanese American University, Byblos, Lebanon;2. Department of Chemistry, University of Oxford, Oxford, UK;3. School of Pharmacy, Department of Pharmaceutical Sciences, Lebanese American University, Byblos Lebanon;1. Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA;2. Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ, USA;3. Drug Safety Research and Development, Pfizer Inc., Groton, USA;4. Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA;1. Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong-Road, Wuhan 430030, PR China;2. School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, PR China;3. Department of Nutrition and Food Hygiene, MOE Key Lab of Environment and Health, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China |
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| Abstract: | Acrylamide is a probable human carcinogen that causes cancer at multiple sites in animal models. However, whether dietary acrylamide intake increases the risk of colorectal cancer in humans is unclear. We examined the association between dietary acrylamide intake and colorectal cancer incidence in the Cohort of Swedish Men, a population-based prospective cohort of 45,306 men who completed a food-frequency questionnaire at enrolment in 1997. During a mean follow-up of 9.3 years, we ascertained 676 incident colorectal cancer cases. Compared with the lowest quartile of acrylamide intake (<29.6 μg/d), the multivariate rate ratios for the highest quartile (?41.7 μg/d) were 0.95 (95% confidence interval (CI) 0.74–1.20) for colorectal cancer, 0.97 (95% CI 0.71–1.31) for colon cancer and 0.91 (95% CI 0.62–1.34) for rectal cancer. In conclusion, this study provides no evidence that dietary acrylamide in amounts typically consumed by Swedish men is associated with risk of colorectal cancer. |
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