Glutathione S-transferase P1 gene polymorphism associated with gastric cancer among Caucasians |
| |
| Authors: | Yong Zhou Ni Li Wen Zhuang Yi-qiong Yin Guan-Jian Liu Tai-Xiang Wu Xun Yao Liang Du Mao-Ling Wei Xiao-Ting Wu |
| |
| Affiliation: | 1. Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA;2. Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA;3. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA;4. NIH Intramural Sequencing Center, National Institutes of Health, 5625 Fishers Lane, Rockville, MD 20852, USA;5. Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA;6. NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, 9000 Rockville Pike, National Institutes of Health, Bethesda, MD 20892, USA |
| |
| Abstract: | Studies investigating the association between glutathione S-transferase P1 (GSTP1) codon 105 polymorphism and gastric cancer risk report conflicting results. The objective of this study was to quantitatively summarise the evidence for such a relationship. Two investigators independently searched the Medline and Embase databases. This meta-analysis included 10 case-control studies, which included 1161 gastric cancer cases and 2847 controls. The combined results based on all studies showed that there was no significant difference in genotype distribution [AA odds ratio (OR) = 1.14, 95% confidence interval (CI) = 0.91, 1.44; AG (OR=0.82, 95% CI = 0.66, 1.03); GG (OR = 1.11, 95% CI = 0.55, 2.24)] between gastric cancer and non-cancer patients. When stratifying for race, results were similar except that patients with gastric cancer had a significantly higher frequency of AA (OR = 1.53, 95% CI = 1.14, 2.06) and lower frequency of AG (OR = 0.70, 95% CI = 0.55, 0.89) than non-cancer patients among Caucasians. When stratifying by the location and Lauren’s classification of gastric cancer, we observed no statistically significant differences in genotype distribution. This meta-analysis suggests that the GSTP1 codon 105 polymorphism may be associated with gastric cancer among Caucasians. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
