216例氟喹诺酮类药品不良反应的回顾性分析

目的：探讨氟喹诺酮类药物不良反应的临床表现及其分布情况；方法：对临床使用氟喹诺酮类药物治疗出现不良反应的患者采用回顾性调查与分析；结果：男性患者明显多于女性患者，不良反应主要发生在神经系统、过敏反应、皮肤及其附件，局部和口服的不良反应发生率明显低于肌肉注射和静脉注射；结论：对于氟喹诺酮类药物应合理使用，严格掌握其适应症、禁忌症及其单独与联合用药量，尽量避免不合理的联合用药，明确其发生不良反应的机制，降低其不良反应发生率，更好地发挥其临床疗效。

Retrospectively Survey and Analysis of the Adverse Drug Reaction in 216 Patients Using Fluoroquinolones

Objective By analyzing 216 advense drug reaction reports received in a hospital,we explore the clinical manifestations of fluoroquinolones＇ adverse reactions and their distribution. Mothods In this article we retrospectively survey and analyze the adverse reactions that occur in patients using fluoroquinolones. Results We find Male patients significantly more than female patients, adverse events occurred mainly in the nervous system, allergic reactions, skin and its annexes, and local and oral incidence of adverse reactions was significantly lower than intramuscular injection and intravenous injection.Conlusion Fluoroquinolones should be rationally used. We should strictly control their indications, con-traindications and the quantity of separate and combined to avoid unreasonable use. We should make its mechanism clear to decrease the occurrence rate of adverse reactions and play its clinical efficacy better.