载体对粉雾剂粉末流动性的影响

目的　研究载体对粉雾剂粉末流动性的影响 ,确定适宜的粉雾剂载体和载体的介入方法。方法　以硫酸沙丁胺醇为模型药物 ,以休止角为流动性指标 ,研究不同类型、大小的乳糖载体 ,对物理混合型硫酸沙丁胺醇粉雾剂粉末流动性的影响 ;以乳糖、甘露醇、甘氨酸为内加载体 ,采用喷雾干燥微粉化方法 ,制备微粉型硫酸沙丁胺醇粉雾剂 ,并进一步考察泊洛沙姆对微粉流动性的影响。结果　重结晶乳糖休止角较市售乳糖小 ;在喷雾干燥工艺处方中 ,加入适量的泊洛沙姆 ,可明显增加以乳糖和甘氨酸为载体的粉雾剂微粉流动性 ,其中以甘氨酸为载体 ,含 2 %泊洛沙姆的微粉型硫酸沙丁胺醇粉雾剂休止角最小35 .5 1°± 0 .2 5° ,流动性最好。结论　采用内加载体直接喷雾技术 ,并加入适量泊洛沙姆 ,可制得流动性良好的粉雾剂

Effects of different carriers on flowability of inhalation powders

OBJECTIVE To investigate the effects of different carriers on flowability of inhalation powders for selecting the suitable carrier and preparation technique.METHOD The micronised salbutamal sulfate was mixed with various lactose carriers.The inhalation powder formulations were further prepared by spray drying with lactose,mannitol or glycin, containing poloxamer or not.The powder flowability was evaluated by determining the reposed angle.RESULT The recrystallized lactose had smaller reposed angle than that of general lactose.The inhalation performance of the powder prepared by spray drying using lactose or glycin carrier was improved by addition of poloxamer. For the addition of 2% poloxamer to mannitol carrier, there was the smallest reposed angle than the others.CONCLUSION The fine dry powder inhalers was prepared by spray drying with addition of poloxamer.