药物促进冠脉支架置入术后血管再内皮化

经皮冠状动脉球囊扩张和支架置入术是目前治疗冠心病的重要手段。早期的冠脉支架为金属裸支架（BMS），由于BMS置入术后冠状动脉的再狭窄率较高，药物涂层支架（DES）应运而生。DES通过抑制血管内膜的增生降低支架置入术后再狭窄，但同时也带来了内皮延迟愈合，内皮化延迟是支架内晚期血栓发生的基础，晚期血栓常可带来非常严重的后果。目前已知很多药物可促进血管再内皮化，预防晚期血栓的发生。本文将重点就晚期血栓发生的机制、常见促进再内皮化的药物如粒细胞集落刺激因子、过氧化物酶体增殖物激活受体激动剂、促红细胞生成素、雌激素、他汀的机制及研究现状进行综述。

Drugs promoting vascular reendothelialization after coronary stenting

Percutaneous coronary angioplasty and stenting is an important treatment for coronary heart disease. The early stent is bare metal stent （BMS）, which causes more coronary restenosis than drug eluting steuts（DES）. Risk of restenosis in DES is lower besause it inhibits vascular endodermis hyperplasia. But DES still leads to delayed endothelialization, which is believed as basis of stent thrombosis.Late thrombosis often bring very serious consequences. Many drugs are known to promote vascular reendothelialization and prevent late thrombosis.This article will focus on the mechanism of late thrombosis, and make summary of the drugs promoting reendothelialization, such as granulocyte colony stimulating factor, peroxisome proliferator-activated reeeptoragonists,erythropoietin, estrogen andstatins.