A new experimental model of obstructive hydrocephalus in the rat: the micro-balloon technique |
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Authors: | D.-S. Kim Shizuo Oi Mitsuru Hidaka Osamu Sato Joong-Uhn Choi |
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Affiliation: | (1) Department of Neurosurgery, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea Tel.: +82-2-361-5620 Fax: +82-2-393–9979, KR;(2) Department of Neurosurgery, Tokai University School of Medicine, Japan, JP |
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Abstract: | We used three types of specialized micro-balloons 0.7–1.35 mm in outer diameter instead of kaolin to develop a reproducible rat model of hydrocephalus with a low experimental mortality. The micro-balloon was inserted 6 mm deep into the cisterna magna via a burr hole immediately behind the lambda. The angle of introduction was 50°. We also set up kaolin-induced hydrocephalic models in 25 rats as controls. The kaolin model revealed 52% mortality with an 80% induction rate of hydrocephalus, while the balloon model showed 9% mortality with a 60% induction rate. Balloon-induced hydrocephalus was maximal at 1 week and tended to decrease after 2–3 weeks. The pathological findings were not different between the two models. We concluded that the micro-balloon model for hydrocephalus is an easily reproducible model with low experimental mortality. Received: 2 March 1998 Revised: 21 July 1998 |
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Keywords: | Hydrocephalus model Kaolin Micro-balloon Rat |
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